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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor Abrahamsohn,I.A. (1) BABINET,CHARLES (1) COHEN-TANNOUDJI,MICHEL (1) Palavra-chave Knock-out mice (2) Conditional mutations (1) Embryonic stem cells (ES) (1) Gene ''targeting'' (1) Genome (1) Innate immunity (1) Interferon-gamma (1) Interleukin-10 (1) Interleukin-12 (1) TNF-alpha (1) Trypanosoma cruzi (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2001 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cytokines in innate and acquired immunity to Trypanosoma cruzi infection BJMBR Abrahamsohn,I.A.. Resistance to Trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. This review focuses on the role of IL-10, TNF-<FONT FACE="Symbol">a</font>, IFN-<FONT FACE="Symbol">g</font> and IL-12 in controlling T. cruzi replication by the innate and specific immune systems of the vertebrate host. A study performed on mice with disrupted recombinase-activating genes (RAG/KO), which lack T and B lymphocytes, revealed the importance of IL-12, IFN-<FONT FACE="Symbol">g</font> and TNF-<FONT FACE="Symbol">a</font> in the resistance against T. cruzi mediated by the innate immune system. In addition, data from experiments using IL-10 KO, RAG/KO and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Interferon-gamma; Interleukin-12; TNF-alpha; Interleukin-10; Innate immunity; Knock-out mice. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100015 Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology Anais da ABC (AABC) BABINET,CHARLES; COHEN-TANNOUDJI,MICHEL. The ability to introduce genetic modifications in the germ line of complex organisms has been a long-standing goal of those who study developmental biology. In this regard, the mouse, a favorite model for the study of the mammals, is unique: indeed not only is it possible since the late seventies, to add genes to the mouse genome like in several other complex organisms but also to perform gene replacement and modification. This has been made possible via two technological breakthroughs: 1) the isolation and culture of embryonic stem cells (ES), which have the unique ability to colonize all the tissues of an host embryo including its germ line; 2) the development of methods allowing homologous recombination between an incoming DNA and its cognate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Embryonic stem cells (ES); Genome; Gene ''targeting''; Knock-out mice; Conditional mutations. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000300007 Registros recuperados: 2 Primeira ... 1 ... Última

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